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FOXO4-DRI at 25 mM concentration selectively induced p53 nuclear exclusion and apoptosis in the senescent Leydig cells, confirmed by Annexin V-FITC/PI apoptosis assays and immunofluorescent staining of Ser15-phospho-p53 foci

While the results of the Phase III randomized controlled trial [103] demonstrates the superiority of SER-109 over placebo, we question whether other treatment options indicated to prevent rCDI, such as ZINPLAVA TM , would be a more appropriate comparator

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Thymosin beta-4 promotes tissue regeneration by actin modulation. Annals of the New York Academy of Sciences , 2007